Chetboun M & al., Association between primary graft function and 5-year outcomes of islet allogeneic transplantation in type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry. Lancet Diabetes Endocrinol. 2023 Jun;11(6):391-401. doi : 10.1016/S2213-8587(23)00082-7 La greffe d’îlots de Langherans est aujourd’hui une option thérapeutique […]
Forlenza GP, et al. Effect of Verapamil on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes: A Randomized Clinical Trial. JAMA. 28 mars 2023;329(12):990-90. La surexpression de la protéine TRXIP (protéine d’interaction avec la thiorédoxine) chez les souris induit l’apoptose des cellules bêta et est impliquée dans la mort de […]
R. Paul Wadwa, Zachariah W. Reed, Bruce A. Buckingham, et al. Trial of Hybrid Closed-Loop Control in Young Children with Type 1 Diabetes. N Engl J Med 2023;388:991-1001. doi : 10.1056/NEJMoa2210834 Le traitement du diabète de type 1 (DT1) chez les enfants de moins de 6 ans est un véritable défi en raison […]
Nicolette R. den Braver, Joline W.J. Beulens, C. Fangyun Wu, & al. Higher Neighborhood Drivability Is Associated With a Higher Diabetes Risk in Younger Adults: A Population-Based Cohort Study in Toronto, Canada. Diabetes Care 2023;46(00):1–8. doi : 10.2337/dc22-1549 L’augmentation de la prévalence du diabète est directement liée à l’urbanisation de nos espaces de […]
Nissen SE & al., Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. N Engl J Med. 2023 Apr 13;388(15):1353-1364. doi : 10.1056/NEJMoa2215024 La prescription de statines est devenue le gold-standard pour la réduction du LDL cholestérol (LDLc) et in fine du risque cardiovasculaire (CV) [1]. Néanmoins, entre 7 et 29% des patients décrivent […]
Al-Ozairi E, et al. Glucagon-like peptide-1 agonists combined with sodium-glucose cotransporter-2 inhibitors reduce weight in type 1 diabetes. Obesity. 2023;31(3). doi : 10.1002/oby.23677 Les analogues du GLP-1 (Glucagon like peptide-1, aGLP-1) et les inhibiteurs du SGLT2 (cotransporteur sodium-glucose de type 2, iSGLT2) sont de plus en plus utilisés pour le traitement du diabète […]
Høgild ML, Hjelholt AJ, Hansen J, et al. Ketone Body Infusion Abrogates Growth Hormone-Induced Lipolysis and Insulin Resistance. J Clin Endocrinol Metab. 2023;108(3):653-664. doi : 10.1210/clinem/dgac595 Les corps cétoniques (CC), produits par le foie via la ß-oxydation des acides gras libres (AGL), sont utilisés comme une source d’énergie alternative en cas de stress […]
Jenny Dimakos, Ying Cui, Robert W. Platt, Christel Renoux, Kristian B. Filion, and Antonios Douros, Concomitant Use of Sulfonylureas and b-Blockers and the Risk of Severe Hypoglycemia Among Patients With Type 2 Diabetes: A Population-Based Cohort Study, Diabetes Care 2023;46(2):377–383. doi : 10.2337/dc22-1584 Les bêtabloquants (BB) ont des effets bénéfiques bien établis dans […]
Feig DS. & al., Outcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomized controlled trial. Lancet Diabetes Endocrinol. 2023 Mars. doi : 10.1016/S2213-8587(23)00004-9 Les recommandations actuelles ne positionnent pas la metformine comme une option thérapeutique de première […]
Brodersen K, et al. Comparable Effects of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass on Basal Fuel Metabolism and Insulin Sensitivity in Individuals with Obesity and Type 2 Diabetes. J Diabetes Res. 2022:5476454. doi : 10.1155/2022/5476454 La chirurgie bariatrique est un traitement efficace de l’obésité et du diabète de type 2 (DT2) [1,2]. La […]
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