Bariatric Surgery versus Intensive Medical Therapy for Diabetes – 3-Year Outcomes. Schauer PR, Bhatt DL, Kirwan JP, Wolski K, Brethauer SA, Navaneethan SD, Aminian A, Pothier CE,Kim ES, Nissen SE, Kashyap SR; the STAMPEDE Investigators. N Engl J Med. 2014 Mar 31. doi: 10.1056/NEJMoa1401329 La chirurgie bariatrique est un traitement efficace du diabète […]
Dayeh et al. Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion, PlosGenetics, March 2014. doi: 10.1371/journal.pgen.1004160 La méthylation de cytosine en 5-méthylcytosine dans les dimères CpG (Cytosine-Guanine, p représentant le pont phosphodiester entre les deux bases) de l’ADN peut influencer […]
Lincoff AM et al, for the AleCardio Investigators. Effect of Aleglitazar on Cardiovascular Outcomes After Acute Coronary Syndrome in Patients With Type 2 Diabetes Mellitus. The AleCardio Randomized Clinical Trial. JAMA 2014;311:1515-25 doi: 10.1001/jama.2014.3321 Les pathologies cardiovasculaires restent la première cause de mortalité chez les patients diabétiques. Même si la prise en charge […]
Quiang G et al. Identification of a small molecular insulin receptor agonist with potent antidiabetes activity. Diabetes 2014, 63 : 1394-1409. doi: 10.2337/db13-0334 La mise au point de traitements alternatifs à l’insulinothérapie sous-cutanée, tant dans le cadre du diabète de type 1 que de type 2, reste un challenge majeur. La recherche d’autres […]
Changes in diabetes-related complications in the United States, 1990-2010. Gregg EW1, Li Y, Wang J, Burrows NR, Ali MK, Rolka D, Williams DE, Geiss L. N Engl J Med. 2014 Apr 17;370(16):1514-23. doi: 10.1056/NEJMoa1310799 Au cours des 30 dernières années, le traitement des patients diabétiques a considérablement évolué. Les grandes études d’intervention, notamment le DCCT [1], l’UKPDS [2] et plus récemment les essais ACCORD […]
Wang et al. Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex, Nature Medicine, 20 April 2014. doi: 10.1038/nm.3527 Chez les organismes inférieurs, comme Caenorhabditis elegans et Drosophila melanogaster, l’homéostasie énergétique est modulée presque exclusivement par des structures neuronales sécrétant des neuropeptides comme l’insuline [1, 2]. Chez […]
Lexis CP, van der Horst IC, et GIPS-III Investigators. Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: the GIPS-III randomized clinical trial. JAMA. 2014 Apr 16;311(15):1526-35. doi:10.1001/jama.2014.3315 La reperfusion précoce des patients présentant un infarctus du myocarde avec élévation du segment ST (STEMI) réduit les lésions […]
Wang Y et al. Proinsulin-Transferin fusion protein as a novel long-acting insulin analog for the inhibition of hepatic glucose production. Diabetes 2014, 63 : 1779-1788. doi: 10.2337/db13-0973 Le développement des analogues lents de l’insuline a jusqu’ici été centré sur leurs propriétés cinétiques, utilisant différents artifices 1-3 : ralentissement de la résorption sous-cutanée (par précipitation […]
Eating two larger meals a day (breakfast and lunch) is more effective than six smaller meals in a reduced-energy regimen for patients with type 2 diabetes: a randomised crossover studyKahleova H, Belinova L, Malinska H, Oliyarnyk O, Trnovska J, Skop V, Kazdova L, Dezortova M, Hajek M, Tura A, Hill M, Pelikanova T. Diabetologia. […]
Martínez et al. In Utero Undernutrition in Male Mice Programs Liver Lipid Metabolism in the Second-Generation Offspring Involving Altered Lxra DNA Methylation, Cell Metabolism, 30 April 2014. doi: 10.1016/j.cmet.2014.03.026 Une nutrition riche en glucides et en lipides est un facteur prédisposant au diabète de type 2 (DT2), non seulement pour les personnes directement […]
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