Schipper HS, et al. Natural killer T cells in adipose tissue prevent insulin resistance. J Clin Invest. 2012 September 4; 122(9): 3343–3354 Published online 2012 August 6. doi: 10.1172/JCI62739 Le tissu adipeux joue un rôle important dans la sensibilité de l’organisme à l’insuline par sa capacité à stocker les calories en excès et […]
Arya E. Mehran et al. Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production. Cell Metabolism 16, 723–737, December 5, 2012. doi: 10.1016/j.cmet.2012.10.019 La prévalence de l’obésité augmente fortement dans le monde. Des variants génétiques de prédisposition ont été identifiés [1], la suralimentation joue un rôle prépondérant mais la cascade des événements physiopathologiques […]
Ziegler AG, Wallner M, Kaiser I, Rossbauer M, Harsunen MH, Lachmann L, Maier J, Winkler C, Hummel S. Long-term protective effect of lactation on the development of type 2 diabetes in women with recent gestational diabetes mellitus. Diabetes 2012;61: 3167-3171. doi: 10.2337/db12-0393 Les bienfaits du lait maternel sur la santé future de l’enfant […]
Chen Y. et al. Therapeutic effects of PPARα agonists on diabetic retinopathy in type 1 diabetic models. Diabetes; epub-ahead of print 05 Oct 2012. doi: 10.2337/db11-0413 Les fibrates sont des ligands du récepteur nucléaire PPARα (peroxisome proliferator-activated receptor α) qui ont été développés comme hypolipémiants (i.e. hypotriglycéridémiants essentiellement). Les dernières études de morbi-mortalité […]
Ceriello A, et al. Evidence that hyperglycemia after recovery from hypoglycemia worsens endothelial function and increases oxidative stress and inflammation in healthy control subjects and subjects with type 1 diabetes. Diabetes. 2012 Nov;61(11):2993-7. doi: 10.2337/db12-0224 L’excursion glycémique postprandiale a des effets toxiques sur l’endothélium vasculaire, en générant du stress oxydant. En conséquence, l’endothélium […]
Hoshino J, et al. Developing an HbA1c-Based Equation to Estimate Blood Glucose in Maintenance Hemodialysis Patients. Diabetes Care. 2012 Dec 13. [Epub ahead of print]. doi: 10.2337/dc12-1019 Shafi T et al. Serum Fructosamine and Glycated Albumin and Risk of Mortality and Clinical Outcomes in Hemodialysis Patients. Diabetes Care. 2012 Dec 18. [Epub ahead of print]. […]
Buse JB, Nauck M, Forst T et al. Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study. Lancet, online November 7 2012. doi: 10.1016/S0140-6736(12)61267-7 En dépit de résultats pour l’heure sans doute inférieurs aux attentes des cliniciens, la classe des agonistes des récepteurs du […]
Stanford K.I. et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 2012 [Epub ahead of print, December 10 2012]. doi: 10.1172/JCI62308 Le tissu adipeux brun (TAB) est au cœur du métabolisme énergétique. Ces dernières années, des travaux ont démontré l’existence de TAB fonctionnel chez l’homme adulte [1-3], faisant […]
Association of an intensive lifestyle intervention with remission of type 2 diabetes. Gregg EW et al. Look AHEAD Research Group. JAMA. 2012 Dec 19;308(23):2489-96. doi: 10.1001/jama.2012.67929 Classiquement, le diabète de type 2 (DT2) est considéré comme une maladie évolutive qui associe une insulino-résistance et une insulinopénie de degré variable. Cette notion de progression […]
Sophie Lecompte et al. Genetic and Molecular Insights Into the Role of PROX1 in Glucose Metabolism. Diabetes [Epub ahead of print], December 28, 2012. doi: 10.2337/db12-0864 L’augmentation spectaculaire de la prévalence du diabète de type 2 au cours des dernières décennies est étroitement associée à l’occidentalisation des modes de vie. L’obésité (surtout centrale) […]
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