Mingrone G, Panunzi S, De Gaetano A, Guidone C, Iaconelli A, Leccesi L, Nanni G, Pomp A, Castagneto M, Ghirlanda G, Rubino F. Bariatric surgery versus conventional medical therapy for type 2 diabetes. N Engl J Med 2012 Mar 26 [Epub ahead of print]. doi: 10.1056/NEJMoa1200111 Schauer PR, Kashyap SR, Wolski K, Brethauer […]
Heller S. et al. Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal- bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus type 1) : a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet 2012 ; 379 : 1489-97. doi: 10.1016/S0140-6736(12)60204-9 L’insuline degludec (Novo Nordisk®) est une nouvelle […]
Jun Okabe J, et al. Distinguishing Hyperglycemic Changes by Set7 in Vascular Endothelial Cells. Circ Res. 2012;110:1067-1076. doi: 10.1161/CIRCRESAHA.112.266171 Dès les années 80, Engerman a observé que des chiens diabétiques développaient une rétinopathie, même si un traitement efficace de l’hyperglycémie était entrepris après 2 ans de diabète non contrôlé (Engerman, Diabetes 1987). Quelques […]
Van Abeelen Annet F.M. et al. Famine Exposure in the Young and the Risk of Type 2 Diabetes in Adulthood. Diabetes 61:2255–2260, 2012. doi: 10.2337/db11-1559 Certains auteurs soutiennent qu’une dénutrition durant la période de développement et de croissance, incluant la vie fœtale et l’enfance, est à l’origine de phénomènes d’adaptations [1,2] certes bénéfiques […]
Gruden G, Barutta F, Chaturvedi N, Schalkwijk C, Stehouwer CD, Witte DR, Fuller JH, Cavallo Perin P, Bruno G. Severe hypoglycemia and cardiovascular disease incidence in type 1 diabetes – The EURODIAB Prospective Complications Study. Diabetes Care published on line May 14, 2012. doi: 10.2337/dc11-1531 Au cours du diabète, la survenue d’hypoglycémies est […]
Gier B. et al. Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the KrasG12D mouse model. Diabetes 2012 ; 61 : 1250-62. doi: 10.2337/db11-1109 doi: 10.2337/db12-er08 Nyborg N.C.B. et al. The human GLP-1 analog liraglutide and the […]
Schipper HS, et al. Natural killer T cells in adipose tissue prevent insulin resistance J Clin Invest. 2012 September 4; 122(9): 3343–3354 Published online 2012 August 6. doi: 10.1172/JCI62739 Le tissu adipeux joue un rôle important dans la sensibilité de l’organisme à l’insuline par sa capacité à stocker les calories en excès et […]
Banga A, et al. In vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15336-41. Epub 2012 Sep 4. doi: 10.1073/pnas.1201701109 Tous les patients atteints de diabète de type 1 attendent avec impatience qu’une solution pérenne de remplacement de la fonction β […]
Carnethon MR, De Chavez PJD, Biggs ML, Lewis CE, Pankow JS, Bertoni AG, Golden SH, Liu K, Mukamal KJ, Campbell-Jenkins B, Dyer AR. Association of weight status with mortality in adults with incident diabetes. JAMA 2012;308:581-590. doi: 10.1001/jama.2012.9282 Un rôle protecteur paradoxal du surpoids et de l’obésité est démontré dans certaines pathologies (insuffisance […]
Pal D. et al. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med 2012 ; 18 : 1279-85. doi: 10.1038/nm.2851 La fétuine A est une glycoprotéine sécrétée par le foie. Également connue sous le nom de α2-Heremans-Schmid glycoprotéine, elle joue un rôle dans le métabolisme osseux et […]
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