Fetal exposure to maternal type 1 diabetes is associated with renal dysfunction at adult age. Khalil CA, et al. Diabetes. 2010 Oct;59(10):2631-6. Les patients diabétiques de type 1, jeunes adultes, nous interrogent souvent sur les risques pour leurs enfants : il est généralement sous-entendu dans leur question qu’ils parlent du risque de diabète […]
Andersson C et al. Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study. Diabetologia 2010, on line first. doi: 10.1007/s00125-010-1906-6 Evans JMM et al. Effect of metformin on mortality in patients with heart failure and type 2 diabetes mellitus. Am J […]
Welsh G.I. et al. Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metabolism 2010 ; 12 : 329-340. La néphropathie diabétique représente, à l’heure actuelle, la première cause d’insuffisance rénale terminale et de dialyse dans les pays occidentaux. Sur le plan moléculaire, la néphropathie diabétique est secondaire à […]
Toshihiro Kobayashi et al. Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells. Cell 142, 787–799, September 3, 2010. L’objectif de la thérapie cellulaire est de remplacer, chez un patient, un organe déficient par des cellules greffées, ce qui permet restaurer une fonction et parfois d’éviter un traitement. […]
Risk of Cardiovascular Disease Events in Patients with Type 2 Diabetes Prescribed the GLP-1 Receptor Agonist Exenatide Twice Daily or Other Glucose-Lowering Therapies: A Retrospective Analysis of the LifeLinkTM Database Best JH, et al. Diabetes Care Publish Ahead of Print, published online October 7, 2010. Contexte : l’histoire récente prouve que les promesses […]
Cholesterol Treatment Trialists’ (CTT) Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170000 participants in 26 randomised trials. Lancet 2010;376 : 1670-1681. En 2005, la ‘Cholesterol Treatment Trialists Collaboration’ publiait une méta-analyse compilant les données individuelles de plus de 90000 patients inclus dans 14 études […]
The Look AHEAD Research Group. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus. Arch Intern Med 2010 ; 170 : 1566-1575. Le bénéfice de modifications agressives de l’hygiène de vie, combinant une prise en charge diététique personnalisée et une activité physique régulière, […]
Sheau-Fang Ng et al. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature 2010 467, 963–966. L’obésité et le diabète de type 2 sont deux pathologies dont la prévalence augmente sans cesse. Le mode de vie des patients concernés est bien sûr crucial dans la survenue de ces deux […]
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin, William L Holland et al. NATURE MEDICINE VOLUME 17 | NUMBER 1 | JANUARY 2011. L’adiponectine est une hormone découverte en 1994 (par Scherer, le dernier auteur de cet article) sécrétée de façon spécifique par les adipocytes, décrite comme une « hormone […]
Dufrane D. et al. Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression. Transplantation 2010 ; 90 : 1054-1062. La thérapie cellulaire du diabète de type 1 (DT1) représente un des principaux enjeux des prochaines années. La greffe de pancréas entier ou d’îlots représente […]
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